Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-27T04:08:24Z | - |
dc.date.available | 2016-08-27T04:08:24Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1949-2553 | * |
dc.identifier.other | OAK-15878 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217747 | - |
dc.description.abstract | The suppressor of MEK null (sMEK1) protein possesses pro-apoptotic activities. In the current study, we reveal that sMEK1 functions as a novel anti-angiogenic factor by suppressing vascular endothelial growth factor (VEGF)-induced cell proliferation, migration, and capillary-like tubular structure in vitro. In addition, sMEK1 inhibited the phosphorylation of the signaling components up-and downstream of Akt, including phospholipase C gamma 1 (PLC-gamma 1), 3-phosphoinositide-dependent protein kinase 1 (PDK1), endothelial nitric oxide synthetase (eNOS), and hypoxia-inducible factor 1 (HIF-1 alpha) during ovarian tumor progression via binding with vascular endothelial growth factor receptor 2 (VEGFR-2). Furthermore, sMEK1 decreased tumor vascularity and inhibited tumor growth in a xenograft human ovarian tumor model. These results supply convincing evidence that sMEK1 controls endothelial cell function and subsequent angiogenesis by suppressing VEGFR-2-mediated PI3K/Akt/eNOS signaling pathway. Taken together, our results clearly suggest that sMEK1 might be a novel anti-angiogenic and anti-tumor agent for use in ovarian tumor. | * |
dc.language | English | * |
dc.publisher | IMPACT JOURNALS LLC | * |
dc.subject | sMEK1 tumor suppressor | * |
dc.subject | hypoxic condition | * |
dc.subject | anti-angiogenic activity | * |
dc.subject | ovarian tumor | * |
dc.subject | xenograft model | * |
dc.title | sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1 alpha signaling pathways | * |
dc.type | Article | * |
dc.relation.issue | 31 | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 31830 | * |
dc.relation.lastpage | 31843 | * |
dc.relation.journaltitle | ONCOTARGET | * |
dc.identifier.wosid | WOS:000363185200116 | * |
dc.author.google | Kim, Boh-Ram | * |
dc.author.google | Seo, Seung Hee | * |
dc.author.google | Park, Mi Sun | * |
dc.author.google | Lee, Seung-Hoon | * |
dc.author.google | Kwon, Youngjoo | * |
dc.author.google | Rho, Seung Bae | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |