Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-27T04:08:23Z | - |
dc.date.available | 2016-08-27T04:08:23Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.issn | 1520-6025 | * |
dc.identifier.other | OAK-15861 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217735 | - |
dc.description.abstract | Five new chalcones, 4,2',4'-trihydroxy-3'-[(2E,5E)-7-methoxy-3,7-dimethyl-2,5-octadienyl]chalcone (1), (+/-)-4,2',4'-trihydroxy-3'-[(2E)-6-hydroxy-7-methoxy-3,7-dimethyl-2-octenyl]chalcone (2), 4,2',4'-trihydroxy-3'-[(2E)-3-methyl-5-(1,3-dioxolan-2-yl)-2-pentenyl]chalcone (3), 2',3'-furano-4-hydroxy-4'-methoxychalcone (4), and (+/-)-4-hydroxy-2',3'-(2,3-dihydro-2-methoxyfurano)-4'-methoxychalcone (5), were isolated from the aerial parts of Angelica keiskei Koidzumi together with eight known chalcones, 6-13, which were identified as (+/-)-4,2',4'-trihydroxy-3'-[(6E)-2-hydroxy-7-methyl-3-rnethylene-6-octenyl]chalcone (6), xanthoangelol (7), xanthoangelol F (8), xanthoangelol G (9), 4-hydroxyderricin (10), xanthoangelol D (11), xanthoangelol E (12), and xanthoangelol H (13), respectively. Chalcones 1-13 were evaluated for their promoter activity on heat shock protein 25 (hsp25, murine form of human hsp27). Compounds 1 and 6 activated the hsp25 promoter by 21.9- and 29.2-fold of untreated control at 10 mu M, respectively. Further protein expression patterns of heat shock factor 1 (HSF1), HSP70, and HSP27 by 1 and 6 were examined. Compound 6 increased the expression of HSF1, HSP70, and HSP27 by 4.3-, 1.5-, and 4.6-fold of untreated control, respectively, without any significant cellular cytotoxicities, whereas 1 did not induce any expression of these proteins. As a result, 6 seems to be a prospective HSP inducer. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 78 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2481 | * |
dc.relation.lastpage | 2487 | * |
dc.relation.journaltitle | JOURNAL OF NATURAL PRODUCTS | * |
dc.identifier.doi | 10.1021/acs.jnatprod.5b00633 | * |
dc.identifier.wosid | WOS:000363995800022 | * |
dc.identifier.scopusid | 2-s2.0-84945375131 | * |
dc.author.google | Kil, Yun-Seo | * |
dc.author.google | Choi, Seul-Ki | * |
dc.author.google | Lee, Yun-Sil | * |
dc.author.google | Jafari, Mahtab | * |
dc.author.google | Seo, Eun-Kyoung | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |