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Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry

Title
Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry
Authors
Moon, Soo-YeonJung, Seo-HeeBin Kim, U.Kim, Won-Suk
Ewha Authors
김원석
SCOPUS Author ID
김원석scopus
Issue Date
2015
Journal Title
RSC ADVANCES
ISSN
2046-2069JCR Link
Citation
vol. 5, no. 97, pp. 79385 - 79390
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCIE; SCOPUS WOS scopus
Abstract
An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.
DOI
10.1039/c5ra14890a
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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