Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2016-08-27T04:08:11Z | - |
dc.date.available | 2016-08-27T04:08:11Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1017-7825 | * |
dc.identifier.issn | 1738-8872 | * |
dc.identifier.other | OAK-15681 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217632 | - |
dc.description.abstract | Monoamine oxidase (MAO) is found in most cell types and catalyzes the oxidation of monoamines. Three anithiactins (A-C, modified 2-phenylthiazoles) isolated from Streptomyces sp. were tested for inhibitory activity of two isoforms, MAO-A and MAO-B. Anithiactin A was effective and selective for the inhibition of MAO-A, with an IC50 value of 13.0 mu M; however, it was not effective for the inhibition of MAO-B. Anithiactins B and C were weaker inhibitors for MAO-A and MAO-B. Anithiactin A was a reversible and competitive inhibitor for MAO-A with a K-i value of 1.84 mu M. The hydrophobic methyl substituent in anithiactin A may play an important role in the inhibition of MAO-A. It is suggested that anithiactin A is a selective reversible inhibitor for MAO-A, with moderate potency, and can be considered a new potential lead compound for further development of novel reversible inhibitors for MAO-A. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC MICROBIOLOGY & | * |
dc.publisher | BIOTECHNOLOGY | * |
dc.subject | Anithiactin A | * |
dc.subject | monoamine oxidase | * |
dc.subject | Streptomyces sp. | * |
dc.subject | selective inhibitor | * |
dc.subject | competitive inhibitor | * |
dc.title | Inhibition of Monoamine Oxidase by Anithiactins from Streptomyces sp. | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1425 | * |
dc.relation.lastpage | 1428 | * |
dc.relation.journaltitle | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | * |
dc.identifier.doi | 10.4014/jmb.1505.05020 | * |
dc.identifier.wosid | WOS:000363182700004 | * |
dc.identifier.scopusid | 2-s2.0-84941890812 | * |
dc.author.google | Lee, Hyun Woo | * |
dc.author.google | Jung, Won Kyeong | * |
dc.author.google | Kim, Hee Jung | * |
dc.author.google | Jeong, Yu Seok | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Kang, Heonjoong | * |
dc.author.google | Kim, Hoon | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |