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A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet

Title
A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet
Authors
Ok, Hyang MokGebreamanuel, Meron ReguOh, Sang A.Jeon, HyejinLee, Won JunKwon, Oran
Ewha Authors
이원준권오란
SCOPUS Author ID
이원준scopus; 권오란scopus
Issue Date
2015
Journal Title
CALCIFIED TISSUE INTERNATIONAL
ISSN
0171-967XJCR Link1432-0827JCR Link
Citation
vol. 97, no. 6, pp. 624 - 633
Keywords
OvariectomyPostmenopausalOsteoporosisPueraria lobataRehmannia glutinosaExercise
Publisher
SPRINGER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis). Female Sprague-Dawley rats (8 weeks old) were randomized into eight groups: sham-operated rats with low-fat control diet + vehicle, OVX rats with low-fat control diet + vehicle, OVX rats with high-fat diet (HFD) + vehicle, OVX rats with HFD + vehicle + exercise, OVX rats with HFD + PR (400 mg/kg body weight/day p.o.), OVX rats with HFD + PR + exercise, OVX rats with HFD + 17 beta-estradiol (0.5 mg/kg body weight/day p.o.), OVX rats with HFD + 17 beta-estradiol + exercise. Bone microarchitecture, bone turnover markers (e.g., plasma alkaline phosphatase and osteocalcin), expressions of osteogenic and resorptive gene markers in the bone were measured. Eight weeks of PR and/or aerobic exercise improved cortical microarchitecture of the femur and decreased markers of bone turnover and expression of skeletal osteoclastogenic genes in the femur. PR supplementation combined with exercise preserved bone loss induced by estrogen deficiency and should be investigated further as an alternative to hormone replacement therapy for preventing osteoporosis in postmenopausal women.
DOI
10.1007/s00223-015-0057-7
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신산업융합대학 > 체육과학부 > Journal papers
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