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Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal

Title
Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal
Authors
Paik, Man-JeongKim, Hye SunLee, Yun-SilChoi, Hyung DoPack, Jeong-KiKim, NamAhn, Young Hwan
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2016
Journal Title
AMINO ACIDS
ISSN
0939-4451JCR Link1438-2199JCR Link
Citation
vol. 48, no. 1, pp. 213 - 217
Keywords
Metabolomic analysisUrinary polyaminesRadiofrequency identificationGas chromatography-mass spectrometryStar pattern recognition
Publisher
SPRINGER WIEN
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Metabolomic analysis of urinary polyamines (PAs) from rat exposed to 915 MHz radiofrequency identification (RFID) signal for 8 h/day for 2 weeks was performed by gas chromatography-mass spectrometry as N-ethoxycarbonyl/N-pentafluoropropionyl derivatives. Large alterations in nine PA levels including four aliphatic and five acetylated PAs were monitored in sham-exposed and RFID-exposed groups. Total PA and urinary levels of N-1-acetylputrescine, N-1-acetylcadaverine, putrescine, cadaverine, N-1-acetylspermidine, N-8-acetylspermidine, spermidine and spermine were reduced, whereas N-1-acetylspermine was significantly increased after sham and RFID exposure compared with those before exposure. Their levels were normalized to the corresponding group means before exposure and then plotted into star symbol patterns. N-1-Acetylspermine after RFID exposure was 54 % higher compared to the level before RFID exposure, while it was elevated by only 17 % in the sham group. The results suggest that 915 MHz RFID exposure may induce metabolic disturbance of PA. It may also elevate spermidine/spermine acetyltransferase (SSAT) activity. Thus, the present metabolic profiling combined with star pattern recognition method might be useful for understanding the complexity of biochemical events after exposure to RFID signal.
DOI
10.1007/s00726-015-2079-x
Appears in Collections:
약학대학 > 약학과 > Journal papers
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