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LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction
- LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction
- Lee, Jueun; Jung, Youngae; Park, Ju Yeon; Lee, Sang-Hak; Ryu, Do Hyun; Hwang, Geum-Sook
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- 0731-7085; 1873-264X
- vol. 115, pp. 475 - 486
- Myocardial infarction; Gender-related differences; Metabolic profiling; UPLC/Q-TOF MS
- ELSEVIER SCIENCE BV
- SCI; SCIE; SCOPUS
- Myocardial infarction (MI), a leading cause of death worldwide, results from prolonged myocardial ischemia with necrosis of myocytes due to a blood supply obstruction to an area of the heart. Many studies have reported gender-related differences in the clinical features of MI, but the reasons for these differences remain unclear. In this study, we applied ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) and various statistical methods-such as multivariate, pathway, and correlation analyses to identify gender-specific metabolic patterns in polar metabolites in serum from healthy individuals and patients with MI. Patients with diagnosed MI (n =68), and age- and body mass index-matched healthy individuals (n = 68), were included in this study. The partial least-squares discriminant analysis (PLS-DA) model was generated from metabolic profiling data, and the score plots showed a significant gender-related difference in patients with MI. Many pathways were associated with amino acids and purines; amino acids, acylcarnitines, and purines differed significantly between male and female patients with MI. This approach could be utilized to observe gender-specific metabolic pattern differences between healthy controls and patients with MI. (C) 2015 Elsevier B.V. All rights reserved.
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