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Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver

Title
Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver
Authors
Yu, Ji-YeonHa, Jae YeoKim, Kyung-MiJung, Young-SukJung, Jae-ChulOh, Seikwan
Ewha Authors
오세관유지연
SCOPUS Author ID
오세관scopus
Issue Date
2015
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
vol. 20, no. 7, pp. 13041 - 13054
Keywords
licorice extractoxidative liver damageanti-inflammationglycyrrhizic acidliquiritinhepatoprotective effect
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases.
DOI
10.3390/molecules200713041
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의학전문대학원 > 의학과 > Journal papers
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