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dc.contributor.author오세관*
dc.contributor.author유지연*
dc.date.accessioned2016-08-27T04:08:56Z-
dc.date.available2016-08-27T04:08:56Z-
dc.date.issued2015*
dc.identifier.issn1420-3049*
dc.identifier.otherOAK-15430*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/217481-
dc.description.abstractThis study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases.*
dc.languageEnglish*
dc.publisherMDPI AG*
dc.subjectlicorice extract*
dc.subjectoxidative liver damage*
dc.subjectanti-inflammation*
dc.subjectglycyrrhizic acid*
dc.subjectliquiritin*
dc.subjecthepatoprotective effect*
dc.titleAnti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver*
dc.typeArticle*
dc.relation.issue7*
dc.relation.volume20*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage13041*
dc.relation.lastpage13054*
dc.relation.journaltitleMOLECULES*
dc.identifier.doi10.3390/molecules200713041*
dc.identifier.wosidWOS:000368695400084*
dc.identifier.scopusid2-s2.0-84938635888*
dc.author.googleYu, Ji-Yeon*
dc.author.googleHa, Jae Yeo*
dc.author.googleKim, Kyung-Mi*
dc.author.googleJung, Young-Suk*
dc.author.googleJung, Jae-Chul*
dc.author.googleOh, Seikwan*
dc.contributor.scopusid오세관(7404103757)*
dc.contributor.scopusid유지연(57188673252)*
dc.date.modifydate20240118133340*
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의과대학 > 의학과 > Journal papers
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