Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 유지연 | * |
dc.date.accessioned | 2016-08-27T04:08:56Z | - |
dc.date.available | 2016-08-27T04:08:56Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-15430 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217481 | - |
dc.description.abstract | This study provides the scientific basis for the anti-inflammatory effects of licorice extract in a t-BHP (tert-butyl hydrogen peroxide)-induced liver damage model and the effects of its ingredients, glycyrrhizic acid (GA), liquiritin (LQ) and liquiritigenin (LG), in a lipopolysaccharide (LPS)-stimulated microglial cell model. The GA, LQ and LG inhibited the LPS-stimulated elevation of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and interleukin (IL)-6 in BV2 (mouse brain microglia) cells. Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) in the livers of t-BHP-treated mice models. This result suggested that mechanistic-based evidence substantiating the traditional claims of licorice extract and its three bioactive components can be applied for the treatment of inflammation-related disorders, such as oxidative liver damage and inflammation diseases. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | licorice extract | * |
dc.subject | oxidative liver damage | * |
dc.subject | anti-inflammation | * |
dc.subject | glycyrrhizic acid | * |
dc.subject | liquiritin | * |
dc.subject | hepatoprotective effect | * |
dc.title | Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 13041 | * |
dc.relation.lastpage | 13054 | * |
dc.relation.journaltitle | MOLECULES | * |
dc.identifier.doi | 10.3390/molecules200713041 | * |
dc.identifier.wosid | WOS:000368695400084 | * |
dc.identifier.scopusid | 2-s2.0-84938635888 | * |
dc.author.google | Yu, Ji-Yeon | * |
dc.author.google | Ha, Jae Yeo | * |
dc.author.google | Kim, Kyung-Mi | * |
dc.author.google | Jung, Young-Suk | * |
dc.author.google | Jung, Jae-Chul | * |
dc.author.google | Oh, Seikwan | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 유지연(57188673252) | * |
dc.date.modifydate | 20240118133340 | * |