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MR images of mouse brain using clinical 3T MR scanner and 4CH-Mouse coil

Title
MR images of mouse brain using clinical 3T MR scanner and 4CH-Mouse coil
Authors
Lim, Soo MeePark, Eun MiLyoo, In KyoonLee, JunghyunHan, Bo MiLee, Jeong KyongBin Lee, Su
Ewha Authors
임수미이정경박은미류인균이정현
SCOPUS Author ID
임수미scopus; 이정경scopus; 박은미scopus; 류인균scopus
Issue Date
2015
Journal Title
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
ISSN
0374-4884JCR Link1976-8524JCR Link
Citation
vol. 67, no. 1, pp. 237 - 242
Keywords
Ischemic preconditioningCerebral infarctMagnetic resonance imaging
Publisher
KOREAN PHYSICAL SOC
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Objectives: Although small-bore high-field magnets are useful for research in small rodent models, this technology, however, has not been easily accessible to most researchers. This current study, thus, tried to evaluate the usability of 4CH-Mouse coil (Philips Healthcare, Best, the Netherlands) for preclinical investigations in clinical 3T MR scan environment. We evaluated the effects of ischemic preconditioning (IP) in the mouse stroke model with clinical 3T MR scanner and 4CH-Mouse coil. Materials and Methods: Experiments were performed on male C57BL/6 mice that either received the IP or sham operation (control). Three different MR sequences including diffusion weighted images (DWI), T2-weighted images (T2WI), and fluid attenuated inversion recovery (FLAIR) were performed on the mouse brains following 24, 72 hours of middle cerebral artery occlusion (MCAO) and analyzed for infarct lesions. Results: The images showed that the IP-treated mouse brains had significantly smaller infarct volumes compared to the control group. Of the MR sequences employed, the T2WI showed the highest level of correlations with postmortem infarct volume measurements. Conclusions: The clinical 3T MR scanner turned out to have a solid potential as a practical tool for imaging small animal brains. MR sequences including DWI, T2WI, FLAIR were obtained with acceptable resolution and in a reasonable time constraint in evaluating a mouse stroke model brain.
DOI
10.3938/jkps.67.237
Appears in Collections:
의과대학 > 의학과 > Journal papers
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