Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-27T04:08:50Z | - |
dc.date.available | 2016-08-27T04:08:50Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 2041-1723 | * |
dc.identifier.other | OAK-15336 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217419 | - |
dc.description.abstract | Transforming growth factor-beta (TGF-beta) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (T(H)17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-beta receptor-regulated Smads (R-Smads): Smad2 and Smad3 oppositely modify STAT3-induced transcription of IL-17A and retinoic acid receptor-related orphan nuclear receptor, ROR gamma t encoded by Rorc, by acting as a co-activator and co-repressor of STAT3, respectively. Smad2 linker phosphorylated by extracellular signal-regulated kinase (ERK) at the serine 255 residue interacts with STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated Smad3 interacts with STAT3 and protein inhibitor of activated STAT3 (PIAS3) to repress the Rorc and Il17a genes. Our work uncovers carboxy-terminal phosphorylation-independent noncanonical R-Smad-STAT3 signalling network in T(H)17 differentiation. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in T(H)17 differentiation | * |
dc.type | Article | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NATURE COMMUNICATIONS | * |
dc.identifier.doi | 10.1038/ncomms8600 | * |
dc.identifier.wosid | WOS:000358856400002 | * |
dc.identifier.scopusid | 2-s2.0-84937708149 | * |
dc.author.google | Yoon, Jeong-Hwan | * |
dc.author.google | Sudo, Katsuko | * |
dc.author.google | Kuroda, Masahiko | * |
dc.author.google | Kato, Mitsuyasu | * |
dc.author.google | Lee, In-Kyu | * |
dc.author.google | Han, Jin Soo | * |
dc.author.google | Nakae, Susumu | * |
dc.author.google | Imamura, Takeshi | * |
dc.author.google | Kim, Juryun | * |
dc.author.google | Ju, Ji Hyeon | * |
dc.author.google | Kim, Dae-Kee | * |
dc.author.google | Matsuzaki, Koichi | * |
dc.author.google | Weinstein, Michael | * |
dc.author.google | Matsumoto, Isao | * |
dc.author.google | Sumida, Takayuki | * |
dc.author.google | Mamura, Mizuko | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |