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Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

Title
Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
Authors
Won, Tae HyungKim, Chang-KwonLee, So-HyoungRho, Boon JoLee, Sang KookOh, Dong-ChanOh, Ki-BongShin, Jongheon
Ewha Authors
노분조
SCOPUS Author ID
노분조scopusscopus
Issue Date
2015
Journal Title
MARINE DRUGS
ISSN
1660-3397JCR Link
Citation
vol. 13, no. 6, pp. 3836 - 3848
Keywords
dipeptidesapliamidesAplidium spMarfey's analysisbioactivities
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4).
DOI
10.3390/md13063836
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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