Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2016-08-27T04:08:37Z | - |
dc.date.available | 2016-08-27T04:08:37Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0021-9258 | * |
dc.identifier.issn | 1083-351X | * |
dc.identifier.other | OAK-15069 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217287 | - |
dc.description.abstract | Cyclooxgenase-2 (COX-2) knock-out mouse experiments showed that COX-2 was necessary for in vivo allergic inflammation, such as passive cutaneous anaphylaxis, passive systemic anaphylaxis, and triphasic cutaneous allergic reaction. Target-Scan analysis predicted COX-2 as a target of miR-26a and miR-26b. miR-26a/-26b decreased luciferase activity associated with COX-2-3' -UTR. miR-26a/-26b exerted negative effects on the features of in vitro and in vivo allergic inflammation by targeting COX-2. ChIP assays showed the binding of HDAC3 and SNAIL, but not COX-2, to the promoter sequences of miR-26a and miR-26b. Cytokine array analysis showed that the induction of chemokines, such as MIP-2, in the mouse passive systemic anaphylaxis model occurred in a COX-2-dependent manner. ChIP assays showed the binding of HDAC3 and COX-2 to the promoter sequences of MIP-2. In vitro and in vivo allergic inflammation was accompanied by the increased expression of MIP-2. miR-26a/-26b negatively regulated the expression of MIP-2. Allergic inflammation enhanced the tumorigenic and metastatic potential of cancer cells and induced positive feedback involving cancer cells and stromal cells, such as mast cells, macrophages, and endothelial cells. miR-26a mimic and miR-26b mimic negatively regulated the positive feedback between cancer cells and stromal cells and the positive feedback among stromal cells. miR-26a/-26b negatively regulated the enhanced tumorigenic potential by allergic inflammation. COX-2 was necessary for the enhanced metastatic potential of cancer cells by allergic inflammation. Taken together, our results indicate that the miR26a/-26b-COX-2-MIP-2 loop regulates allergic inflammation and the feedback relationship between allergic inflammation and the enhanced tumorigenic and metastatic potential. | * |
dc.language | English | * |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | * |
dc.title | MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells | * |
dc.type | Article | * |
dc.relation.issue | 22 | * |
dc.relation.volume | 290 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 14245 | * |
dc.relation.lastpage | 14266 | * |
dc.relation.journaltitle | JOURNAL OF BIOLOGICAL CHEMISTRY | * |
dc.identifier.doi | 10.1074/jbc.M115.645580 | * |
dc.identifier.wosid | WOS:000355313000051 | * |
dc.identifier.scopusid | 2-s2.0-84930226007 | * |
dc.author.google | Kwon, Yoojung | * |
dc.author.google | Kim, Youngmi | * |
dc.author.google | Eom, Sangkyung | * |
dc.author.google | Kim, Misun | * |
dc.author.google | Park, Deokbum | * |
dc.author.google | Kim, Hyuna | * |
dc.author.google | Noh, Kyeonga | * |
dc.author.google | Lee, Hansoo | * |
dc.author.google | Lee, Yun Sil | * |
dc.author.google | Choe, Jongseon | * |
dc.author.google | Kim, Young Myeong | * |
dc.author.google | Jeoung, Dooil | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |