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Chemical Genetics Approach Reveals Importance of cAMP and MAP Kinase Signaling to Lipid and Carotenoid Biosynthesis in Microalgae

Title
Chemical Genetics Approach Reveals Importance of cAMP and MAP Kinase Signaling to Lipid and Carotenoid Biosynthesis in Microalgae
Authors
Choi, Yoon-ERhee, Jin-KyuKim, Hyun-SooAhn, Joon-WooHwang, HyeminYang, Ji-Won
Ewha Authors
이진규
SCOPUS Author ID
이진규scopus
Issue Date
2015
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN
1017-7825JCR Link1738-8872JCR Link
Citation
vol. 25, no. 5, pp. 637 - 647
Keywords
Microalgal signaling pathwayslipid biosynthesiscarotenoid biosynthesisMAP kinasecAMP signaling
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
In this study, we attempted to understand signaling pathways behind lipid biosynthesis by employing a chemical genetics approach based on small molecule inhibitors. Specific signaling inhibitors of MAP kinase or modulators of cAMP signaling were selected to evaluate the functional roles of each of the key signaling pathways in three different microalgal species: Chlamydomonas reinhardtii, Chlorella vulgaris, and Haematococcus pluvialis. Our results clearly indicate that cAMP signaling pathways are indeed positively associated with microalgal lipid biosynthesis. In contrast, MAP kinase pathways in three microalgal species are all negatively implicated in both lipid and carotenoid biosynthesis.
DOI
10.4014/jmb.1408.08035
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엘텍공과대학 > 식품공학전공 > Journal papers
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