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A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Title
A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men
Authors
Park, Sung KeunChun, HyejinRyoo, Jae-HongLee, Sang WhaLee, Hong SooShim, Kyung WonCho, Choo YonRyu, Dorig-RyeolKo, Taeg SuKim, EugenePark, Se-JinPark, Jai HyungHong, Seok JinHong, Hyun Pyo
Ewha Authors
이상화이홍수심경원류동열전혜진
SCOPUS Author ID
이상화scopus; 이홍수scopus; 심경원scopus; 류동열scopus; 전혜진scopus
Issue Date
2015
Journal Title
CLINICA CHIMICA ACTA
ISSN
0009-8981JCR Link1873-3492JCR Link
Citation
vol. 446, pp. 111 - 116
Keywords
Insulin resistanceHOMA-IRMicroalbuminuria
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P < 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-235) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (P for linear trend = 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men. (C) 2015 Elsevier B.V. All rights reserved.
DOI
10.1016/j.cca.2015.03.043
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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