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dc.contributor.author정병문*
dc.contributor.author황성주*
dc.date.accessioned2016-08-27T04:08:29Z-
dc.date.available2016-08-27T04:08:29Z-
dc.date.issued2015*
dc.identifier.issn1616-301X*
dc.identifier.issn1616-3028*
dc.identifier.otherOAK-14906*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/217204-
dc.description.abstract2D/3D hybrid cell culture systems are constructed by increasing the temperature of the thermogelling poly(ethylene glycol)-poly(L-alanine) diblock copolymer (PEG-L-PA) aqueous solution in which tonsil tissue-derived mesenchymal stem cells and graphene oxide (GO) or reduced graphene oxide (rGO) are suspended, to 37 degrees C. The cells exhibit spherical cell morphologies in 2D/3D hybrid culture systems of GO/PEG-L-PA and rGO/PEG-L-PA by using the growth medium. The cell proliferations are 30%-50% higher in the rGO/PEG-L-PA hybrid system than in the GO/PEG-L-PA hybrid system. When chondrogenic culture media enriched with TGF-beta 3 is used in the 2D/3D hybrid systems, cells extensively aggregate, and the expression of chondrogenic biomarkers of SOX 9, COL II A1, COL II, and COL X significantly increases in the GO/PEG-L-PA 2D/3D hybrid system as compared with the PEG-L-PA 3D systems and rGO/PEG-L-PA 2D/3D hybrid system, suggesting that the GO/PEG-L-PA 2D/3D hybrid system can be an excellent candidate as a chondrogenic differentiation platform of the stem cell. This paper also suggests that a 2D/3D hybrid system prepared by incorporating 2D materials with various surface biofunctionalities in the in situ forming 3D hydrogel matrix can be a new cell culture system.*
dc.languageEnglish*
dc.publisherWILEY-V C H VERLAG GMBH*
dc.title2D and 3D Hybrid Systems for Enhancement of Chondrogenic Differentiation of Tonsil-Derived Mesenchymal Stem Cells*
dc.typeArticle*
dc.relation.issue17*
dc.relation.volume25*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage2573*
dc.relation.lastpage2582*
dc.relation.journaltitleADVANCED FUNCTIONAL MATERIALS*
dc.identifier.doi10.1002/adfm.201500299*
dc.identifier.wosidWOS:000354200000010*
dc.identifier.scopusid2-s2.0-84928729909*
dc.author.googlePark, Jinhye*
dc.author.googleKim, In Young*
dc.author.googlePatel, Madhumita*
dc.author.googleMoon, Hyo Jung*
dc.author.googleHwang, Seong-Ju*
dc.author.googleJeong, Byeongmoon*
dc.contributor.scopusid정병문(7102237959)*
dc.contributor.scopusid황성주(7404626171)*
dc.date.modifydate20240118155902*
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자연과학대학 > 화학·나노과학전공 > Journal papers
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