Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.contributor.author | 전규연 | * |
dc.date.accessioned | 2016-08-27T04:08:27Z | - |
dc.date.available | 2016-08-27T04:08:27Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1860-7179 | * |
dc.identifier.issn | 1860-7187 | * |
dc.identifier.other | OAK-14872 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217184 | - |
dc.description.abstract | Tryptanthrin is an indoloquinazoline alkaloid isolated from indigo. Tryptanthrin and its benzo-annulated derivative, benzo[b]tryptanthrin, inhibit both topoisomerasesI (topoI) and II (topoII) and cause cytotoxicity in several human cancer cell lines. From diverse assessment methods, including cleavage complex stabilization, comet, DNA unwinding/intercalation, topoII ATPase inhibition, ATP competition for topoII, and wound-healing assays, we determined that the mode of action of benzo[b]tryptanthrin is as a DNA non-intercalative and ATP-competitive topoI and II dual catalytic inhibitor. Benzo[b]tryptanthrin induced apoptosis through the cleavage of caspase-3 and PARP in HCT15 colon cancer cells. Additionally, benzo[b]tryptanthrin reversed adriamycin resistance by down-regulation of multidrug resistance protein1 (MDR1) in adriamycin-resistant MCF7 breast cancer cells (MCF7adr) with more potent inhibitory activity than tryptanthrin. Taken together, derivatization by benzo-annulation of tryptanthrin ameliorated the MDR-reversing effect of tryptanthrin and may pave the way to the discovery of a novel potent adjuvant agent for chemotherapy. | * |
dc.language | English | * |
dc.publisher | WILEY-V C H VERLAG GMBH | * |
dc.subject | adriamycin | * |
dc.subject | ATP competitive | * |
dc.subject | benzo[b]tryptanthrin | * |
dc.subject | MDR1 | * |
dc.subject | topoisomerases | * |
dc.title | Benzo[b]Tryptanthrin Inhibits MDR1, Topoisomerase Activity, and Reverses Adriamycin Resistance in Breast Cancer Cells | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 10 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 827 | * |
dc.relation.lastpage | 835 | * |
dc.relation.journaltitle | ChemMedChem | * |
dc.identifier.doi | 10.1002/cmdc.201500068 | * |
dc.identifier.wosid | WOS:000353473600007 | * |
dc.identifier.scopusid | 2-s2.0-84928473722 | * |
dc.author.google | Jun, Kyu-Yeon | * |
dc.author.google | Park, So-Eun | * |
dc.author.google | Liang, Jing Lu | * |
dc.author.google | Jahng, Yurngdong | * |
dc.author.google | Kwon, Youngjoo | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.contributor.scopusid | 전규연(25632526500) | * |
dc.date.modifydate | 20240422124907 | * |