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Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients

Title
Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients
Authors
Song, Tae-JinChang, YoonkyungShin, Min-JeongHeo, Ji HoeKim, Yong-Jae
Ewha Authors
김용재송태진
SCOPUS Author ID
김용재scopus; 송태진scopus
Issue Date
2015
Journal Title
NUTRITION RESEARCH
ISSN
0271-5317JCR Link
Citation
vol. 35, no. 5, pp. 368 - 374
Keywords
Small vessel diseaseFatty acids compositionn-3-polyunsaturated fatty acidsCerebral microbleedsWhite matter changesPerivascular spaces
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease-modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods. The presence and burden of cerebral microbleeds (CMBs), high-grade white matter changes (HWCs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) were investigated. The mean proportion (+/- SD) was 2.0 +/- 0.7 for EPA, 8.9 +/- 1.5 for DHA, and 12.0 +/- 2.1 for Sigma n-3-PUFAs. In total, 46 (20.9%) patients had CMBs, 64 (29.1 %) had HWCs, 57 (25.9%) had HPVSs, and 65 (29.5%) had ALIs. In univariate analyses, CMBs, HWCs, and HPVSs were each negatively correlated with the proportion of EPA, DHA, and Sigma n-3-PUFAs. In the multivariate analysis, a lower proportion of EPA, DHA and Sigma n-3-PUFAs was associated with the presence of CMBs, HWCs and HPVS, but not ALIs. Total SVDs score was inversely correlated with the proportion of EPA, DHA and Sigma n-3-PUFAs. Overall, we found an association between low proportions of plasma n-3-PUFAs and cerebral SVDs pathologies. Further studies are needed to explore the association and potential therapeutic role of FAs in cerebral SVDs. (C) 2015 Elsevier Inc. All rights reserved.
DOI
10.1016/j.nutres.2015.04.008
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의학전문대학원 > 의학과 > Journal papers
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