Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용재 | * |
dc.contributor.author | 송태진 | * |
dc.date.accessioned | 2016-08-27T04:08:26Z | - |
dc.date.available | 2016-08-27T04:08:26Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0271-5317 | * |
dc.identifier.other | OAK-14855 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217172 | - |
dc.description.abstract | Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease-modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods. The presence and burden of cerebral microbleeds (CMBs), high-grade white matter changes (HWCs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) were investigated. The mean proportion (+/- SD) was 2.0 +/- 0.7 for EPA, 8.9 +/- 1.5 for DHA, and 12.0 +/- 2.1 for Sigma n-3-PUFAs. In total, 46 (20.9%) patients had CMBs, 64 (29.1 %) had HWCs, 57 (25.9%) had HPVSs, and 65 (29.5%) had ALIs. In univariate analyses, CMBs, HWCs, and HPVSs were each negatively correlated with the proportion of EPA, DHA, and Sigma n-3-PUFAs. In the multivariate analysis, a lower proportion of EPA, DHA and Sigma n-3-PUFAs was associated with the presence of CMBs, HWCs and HPVS, but not ALIs. Total SVDs score was inversely correlated with the proportion of EPA, DHA and Sigma n-3-PUFAs. Overall, we found an association between low proportions of plasma n-3-PUFAs and cerebral SVDs pathologies. Further studies are needed to explore the association and potential therapeutic role of FAs in cerebral SVDs. (C) 2015 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Small vessel disease | * |
dc.subject | Fatty acids composition | * |
dc.subject | n-3-polyunsaturated fatty acids | * |
dc.subject | Cerebral microbleeds | * |
dc.subject | White matter changes | * |
dc.subject | Perivascular spaces | * |
dc.title | Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 35 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 368 | * |
dc.relation.lastpage | 374 | * |
dc.relation.journaltitle | NUTRITION RESEARCH | * |
dc.identifier.doi | 10.1016/j.nutres.2015.04.008 | * |
dc.identifier.wosid | WOS:000355387000002 | * |
dc.identifier.scopusid | 2-s2.0-84929655795 | * |
dc.author.google | Song, Tae-Jin | * |
dc.author.google | Chang, Yoonkyung | * |
dc.author.google | Shin, Min-Jeong | * |
dc.author.google | Heo, Ji Hoe | * |
dc.author.google | Kim, Yong-Jae | * |
dc.contributor.scopusid | 김용재(36910759200) | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.date.modifydate | 20240304123954 | * |