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Dendrimeric siRNA for Efficient Gene Silencing

Title
Dendrimeric siRNA for Efficient Gene Silencing
Authors
Hong, Cheol AmEltoukhy, Ahmed A.Lee, HyukjinLanger, RobertAnderson, Daniel G.Nam, Yoon Sung
Ewha Authors
이혁진
SCOPUS Author ID
이혁진scopus
Issue Date
2015
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
1433-7851JCR Link1521-3773JCR Link
Citation
vol. 54, no. 23, pp. 6740 - 6744
Keywords
dendrimeric nanostructuresgene silencingpoly(-amino ester)polymeric condensationsiRNA
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(-amino ester), PBAE) to generate stable nanostructures about 160nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.
DOI
10.1002/anie.201412493
Appears in Collections:
약학대학 > 약학과 > Journal papers
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