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Suppression of Splenic Lymphocyte Proliferation by Eucommia ulmoides and Genipin

Title
Suppression of Splenic Lymphocyte Proliferation by Eucommia ulmoides and Genipin
Authors
Yang, GabsikKyoung Seo, EunLee, Je-HyunYoung Lee, Joo
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2015
Journal Title
CHEMISTRY & BIODIVERSITY
ISSN
1612-1872JCR Link1612-1880JCR Link
Citation
vol. 12, no. 4, pp. 538 - 546
Keywords
Cellular immunityHumoral immunityImmunosuppressionMacrophagesLymphocytessplenic
Publisher
WILEY-V C H VERLAG GMBH
Indexed
SCIE; SCOPUS WOS scopus
Abstract
We investigated the modulation of innate and adaptive immune cell activation by Eucommia ulmoidesOliver extract (EUE) and its ingredient genipin. As an innate immunity indicator, the phagocytic activity of macrophages was determined by measuring engulfed, fluorescently labeled Escherichia coli. As a surrogate marker for the respective activation of cellular and humoral adaptive immunity, concanavalin A (ConA) and lipopolysaccharide (LPS) induction of primary splenocyte proliferation was assayed in in vitro and ex vivo systems. EUE and genipin suppressed the proliferation of primary splenic lymphocytes induced by ConA or LPS, but not macrophage phagocytosis. Oral administration of EUE and genipin to mice decreased splenic lymphocyte proliferation induced by ConA or LPS. These results revealed that E. ulmoides and genipin suppressed cellular and humoral adaptive immunity, and they suggest that E. ulmoides and genipin are promising candidates for immunosuppressive drugs that target diseases that involve excessive activation of adaptive immunity.
DOI
10.1002/cbdv.201400376
Appears in Collections:
약학대학 > 약학과 > Journal papers
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