Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-27T04:08:22Z | - |
dc.date.available | 2016-08-27T04:08:22Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 2041-1723 | * |
dc.identifier.other | OAK-14793 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217130 | - |
dc.description.abstract | TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3 beta interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of GSK3 beta expression or its kinase activity drastically reduces the production of inflammatory cytokines and the induction of c-Fos by decreasing ERK and p38 phosphorylation. GSK3 beta physically associates with TRAF6 in a TLR3 ligand poly I:C-dependent manner. TRAF6 is determined to be a direct E3 ligase for GSK3 beta, and TRAF6-mediated GSK3 beta ubiquitination is essential for poly I:C-dependent cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Glycogen synthase kinase 3 beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production | * |
dc.type | Article | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NATURE COMMUNICATIONS | * |
dc.identifier.doi | 10.1038/ncomms7765 | * |
dc.identifier.wosid | WOS:000353702500005 | * |
dc.identifier.scopusid | 2-s2.0-84926395603 | * |
dc.author.google | Ko, Ryeojin | * |
dc.author.google | Park, Jin Hee | * |
dc.author.google | Ha, Hyunil | * |
dc.author.google | Choi, Yongwon | * |
dc.author.google | Lee, Soo Young | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |