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Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp F9A015

Title
Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp F9A015
Authors
Kim, HiyoungYang, InhoRyu, Shin-YoungWon, Dong HwanGiri, Awadut G.Wang, WeihongChoi, HyukjaeChin, JungwookHahn, DongyupKim, EunheeHan, ChulkyeongLee, JihyeNam, Sang-JipHo, Won-KyungKang, Heonjoong
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2015
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link1520-6025JCR Link
Citation
vol. 78, no. 3, pp. 363 - 367
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 mu M, respectively.
DOI
10.1021/np5007586
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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