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One-Photon and Two-Photon Sensing of Biothiols Using a Bis-Pyrene-Cu(II) Ensemble and Its Application To Image GSH in the Cells and Tissues

Title
One-Photon and Two-Photon Sensing of Biothiols Using a Bis-Pyrene-Cu(II) Ensemble and Its Application To Image GSH in the Cells and Tissues
Authors
Hu, YingHeo, Cheol HoKim, GyoungmiJun, Eun JinYin, JunKim, Hwan MyungYoon, Juyoung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2015
Journal Title
ANALYTICAL CHEMISTRY
ISSN
0003-2700JCR Link1520-6882JCR Link
Citation
vol. 87, no. 6, pp. 3308 - 3313
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Glutathione (GSH), cysteine (Cys), and homodysteine (Hcy) are three major biothiols, which play key roles in various biological systems. Accordnigly, the development of imaging probes has been actively studied. We report a new pyrene derivative 1, which showed large fluorescence quenching with Cu2+ at pH 7.4. The ensemble 1-Cu2+ was applied to detect iriothiols. Among the various amino acids, GSH, Cys, and Hcy induced distinct turn-on fluorescence changes. The 1-Cu ensemble was further, applied for GSH detection in living cells.
DOI
10.1021/ac504372w
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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