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Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase

Title
Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase
Authors
Bae, MunhyungKim, HeegyuMoon, KyuhoNam, Sang-JipShin, JongheonOh, Ki-BongOh, Dong-Chan
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2015
Journal Title
ORGANIC LETTERS
ISSN
1523-7060JCR Link1523-7052JCR Link
Citation
vol. 17, no. 3, pp. 712 - 715
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Mohangamides A and B (1-2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.
DOI
10.1021/ol5037248
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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