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Comparison of budesonide and dexamethasone for local treatment of oral chronic graft-versus-host disease

Title
Comparison of budesonide and dexamethasone for local treatment of oral chronic graft-versus-host disease
Authors
Park, Ae RyoungLa, Hyen OhCho, Byung SikKim, Soon JooLee, Byung KooRhie, Jeong YeonGwak, Hye Sun
Ewha Authors
곽혜선이병구이정연
SCOPUS Author ID
곽혜선scopus; 이병구scopusscopus; 이정연scopus
Issue Date
2013
Journal Title
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
ISSN
1079-2082JCR Link
Citation
vol. 70, no. 16, pp. 1383 - 1391
Publisher
AMER SOC HEALTH-SYSTEM PHARMACISTS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose. The results of a prospective study of topical budesonide versus topical dexamethasone therapy for oral manifestations of chronic graft-versus-host- disease (cGVHD) are presented. Methods. In a prospective single-center investigation, a cohort of patients who developed oral symptoms of cGVHD after allogeneic stem cell transplantation were assigned to topical treatment with 0.03% budesonide rinse (group A, n = 26) or 0.01% dexamethasone rinse (group B, n = 24). Diagnosis of oral cGVHD symptoms, clinical staging, and treatment response scoring were performed at baseline and one month later according to current National Institutes of Health consensus criteria. Results. At one-month follow-up, there was a significant decrease in the median oral cGVHD examination score in both groups (p<0.001); the decrease in the median examination score was greater with budesonide versus, dexamethasone therapy (2.5 points versus 1.0 point, p = 0.045). The rates of overall treatment response, including complete and partial responses, were 53.8% and 29.2% in groups A and B, respectively (p = 0.093). In addition, there was a significant decrease from baseline in the median self-rated oral pain severity score in group A (p < 0.001). Conclusion. Patients who received topical budesonide or dexamethasone rinse to treat oral manifestations of cGVHD had decreased cGVHD severity and pain scores after 30 days compared with baseline scores, though no statistical differences were seen between groups.
DOI
10.2146/ajhp120567
Appears in Collections:
약학대학 > 약학과 > Journal papers
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