Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 창동신 | - |
dc.date.accessioned | 2016-08-27T02:08:19Z | - |
dc.date.available | 2016-08-27T02:08:19Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.other | OAK-8379 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216576 | - |
dc.description.abstract | In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.subject | Panax ginseng | - |
dc.subject | Sun ginseng (SE) | - |
dc.subject | Type I collagen | - |
dc.subject | Matrix metalloproteinase-1 | - |
dc.subject | Human skin fibroblasts | - |
dc.title | Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 36 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 61 | - |
dc.relation.lastpage | 67 | - |
dc.relation.journaltitle | JOURNAL OF GINSENG RESEARCH | - |
dc.identifier.doi | 10.5142/jgr.2012.36.1.61 | - |
dc.identifier.wosid | WOS:000299198800007 | - |
dc.author.google | Song, Kyu Choon | - |
dc.author.google | Chang, Tong-Shin | - |
dc.author.google | Lee, Hyejin | - |
dc.author.google | Kim, Jinhee | - |
dc.author.google | Park, Jeong Hill | - |
dc.author.google | Hwang, Gwi Seo | - |
dc.contributor.scopusid | 창동신(7404726037) | - |
dc.date.modifydate | 20190301081000 | - |