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SYNDECAN SIGNALING: WHEN, WHERE AND WHY?

Title
SYNDECAN SIGNALING: WHEN, WHERE AND WHY?
Authors
Multhaupt, H. A. B.Yoneda, A.Whiteford, J. R.Oh, E-SLee, W.Couchman, J. R.
Ewha Authors
오억수
SCOPUS Author ID
오억수scopus
Issue Date
2009
Journal Title
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
ISSN
0867-5910JCR Link
Citation
vol. 60, pp. 31 - 38
Keywords
proteoglycancell adhesionheparan sulphatecytoskeletonreceptortrafficking
Publisher
POLISH PHYSIOLOGICAL SOC
Indexed
SCIE; SCOPUS WOS
Abstract
Syndecans are the only family of transmembrane heparan sulphate proteoglycans Invertebrates all appear to have one Syndecan core protein, but in mammals there are four Examination of the core protein sequences shows that the cytoplasmic domains are the most conserved. This suggests that Syndecans make important interactions and/or signalling contributions. It has been established that all syndecans can interact with proteins of the actin-associated cytoskeleton, but details of signalling have been harder to ascertain However, it appears that Syndecans can signal, primarily to the cytoskeleton, and the details are reviewed here Only for veretebrate syndecan-4 is there substantial detail, and it remains a challenge to dissect the functions and signalling of other vertebrate and invertebrate syndecans.
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자연과학대학 > 생명과학전공 > Journal papers
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