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Chitosan/poly(L-lactic acid) multilayered membrane for guided tissue regeneration

Title
Chitosan/poly(L-lactic acid) multilayered membrane for guided tissue regeneration
Authors
Ku, YoungShim, In KyongLee, Jue YoenPark, Yoon JeongRhee, Sang-HoonNam, Sung HeonPark, Jun BeomChung, Chong PyoungLee, Seung Jin
Ewha Authors
이승진심인경
SCOPUS Author ID
이승진scopus
Issue Date
2009
Journal Title
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN
1549-3296JCR Link
Citation
vol. 90A, no. 3, pp. 766 - 772
Keywords
chitosanPLLAguided tissue regenerationbarrier membrane
Publisher
WILEY-LISS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
A chitosan/Poly(L-lactic acid) (PLLA) Multilayered membrane was prepared for the purpose of guided tissue regeneration (GTR). The membrane was composed of the outer layers of chitosan mesh and the middle layer of nanoporous PLLA membrane. The outer membranes of chitosan fibrous mesh present a highly biocompatible and rough surface for ease of cell adherence. The PLLA membrane is intended to provide mechanical strength to the membrane, thereby preventing epithelial invasion. The PLLA membrane was applied as a local drug delivery carrier for growth factors. Regular pores in PLLA membrane were generated through phase inversion of polymer solution. The membrane retained its integrity during the degradation process in vitro (for up to 8 weeks), which is a requirement for providing enough space in vivo in the GTR procedure. Osteoblasts firmly attached to broad cytoplasmic extensions along with the microfibers of the membrane. The phenotypic expression of cultured osteoblasts on the membrane was measured by a reverse transcriptase-polymerase chain reaction. New bone had formed beneath the chitosan/PLLA membrane. These results suggested that the chitosan/PLLA membranes properly functioned as biocompatible and mechanically stable barriers for GTR. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 766-772, 2009
DOI
10.1002/jbm.a.31846
Appears in Collections:
약학대학 > 약학과 > Journal papers
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