Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-27T02:08:00Z | - |
dc.date.available | 2016-08-27T02:08:00Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-5700 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216347 | - |
dc.description.abstract | Sauchinone, a lignan compound isolated from the root of saururus chinensis, has been recently demonstrated to exhibit anti-inflammatory, activity via the Suppression of NF-kB p65 activity in vitro. In an effort to evaluate the in vivo anti-inflammatory function of sauchinone, we have evaluated the effects of sauchinone on allergen-induced airway inflammation using a murine model of allergic asthma. We observed that marked eosinophilic and lymphocyte infiltration in the BAL fluid were suppressed to a significant degree by sauchinone, and that mucus-secreting goblet cell hyperplasia and collagen deposition in the airways were also ameliorated by administration of sauchinone treatment. Moreover, gene expression of the inflammatory cytokines, IL-13, and IL-5 and eotaxin in the lung, and IL-5 in the draining lymph node were significantly decreased in sauchinone-treated mice. We demonstrated that sauchinone repressed Th2 cell development in vitro and IL-4 production by Th2 cells, and also inhibited GATA-3-mediated IL-5 promoter activity in a close-dependent manner. Collectively, sauchinone ameliorated allergen-induced airway inflammation, in part, by repressing GATA-3 activity for Th2 cell development, indicating the possible therapeutic potential of sauchinone in airway inflammatory diseases including allergic asthma and rhinitis. (C) 2009 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | * |
dc.subject | Sauchinone | * |
dc.subject | Allergen-induced airway inflammation | * |
dc.subject | GATA-3 | * |
dc.subject | Th2 cell development | * |
dc.subject | Airway inflammatory diseases | * |
dc.title | Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 385 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 204 | * |
dc.relation.lastpage | 209 | * |
dc.relation.journaltitle | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | * |
dc.identifier.doi | 10.1016/j.bbrc.2009.05.039 | * |
dc.identifier.wosid | WOS:000267037300015 | * |
dc.author.google | Min, Hyun Jung | * |
dc.author.google | Won, Hee Yeon | * |
dc.author.google | Kim, Young Choong | * |
dc.author.google | Sung, Sang Hyun | * |
dc.author.google | Byun, Mi Ran | * |
dc.author.google | Hwang, Jun-Ha | * |
dc.author.google | Hong, Jeong-Ho | * |
dc.author.google | Hwang, Eun Sook | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |