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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity

Title
Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity
Authors
Kim, Bang HyunWon, Young SukKim, Dae YongKim, BoraKim, Eun-YoungYoon, MijungOh, Goo Taeg
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2009
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link
Citation
vol. 42, no. 2, pp. 91 - 95
Keywords
EstrogenLPLObesityPPAR alphaSignaling crosstalk
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Peroxisome proliferator-activated receptor a and estrogen are believed to he involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E(2), causing obesity in vivo. [BMB reports 2009; 42(2): 91-95]
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자연과학대학 > 생명과학전공 > Journal papers
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