View : 15 Download: 0
Antipathogenic Properties of Green Tea Polyphenol Epigallocatechin Gallate at Concentrations below the MIC against Enterohemorrhagic Escherichia coli O157:H7
- Antipathogenic Properties of Green Tea Polyphenol Epigallocatechin Gallate at Concentrations below the MIC against Enterohemorrhagic Escherichia coli O157:H7
- Lee, Kang-Mu; Kim, Wan-Seok; Lim, Jeesun; Nam, Sunyoung; Youn, Min; Nam, Seong-Won; Kim, Younghoon; Kim, Sae-Hun; Park, Woojun; Park, Sungsu
- Ewha Authors
- Issue Date
- Journal Title
- JOURNAL OF FOOD PROTECTION
- vol. 72, no. 2, pp. 325 - 331
- INT ASSOC FOOD PROTECTION
- SCI; SCIE; SCOPUS
- The inhibitory effects of green tea polyphenol epigallocatechin gallate (EGCG) on virulence phenotypes and gene expression regulated by quorum sensing (QS) in Escherichia coli O15TH7 were demonstrated at concentrations of 1 to 100 mu g/ml, which are lower than the MIC (539 +/- 22 mu g/ml). At 25 mu g/ml, the growth rate was not affected, but autoinducer 2 concentration, biofilm formation, and swarm motility decreased to 13.2, 11.8, and 50%, respectively. Survival at 5 days of nematodes (Caenorhabditis elegans) that were fed the pathogen without and with EGCG were 47.1 and 76%, respectively. Real-time PCR data indicated decreased transcriptional level in many quorum sensing-regulated virulence genes at 25 mu g/ml. Our results suggest that EGCG at concentrations below its MIC has significant antipathogenic effects against E. coli O157:H7.
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.