View : 31 Download: 0

Role of reactive oxygen species in the pathogenesis of diabetic nephropathy

Title
Role of reactive oxygen species in the pathogenesis of diabetic nephropathy
Authors
Ha, HunjooHwang, In-APark, Jong HeeLee, Hi Bahl
Ewha Authors
하헌주
SCOPUS Author ID
하헌주scopus
Issue Date
2008
Journal Title
DIABETES RESEARCH AND CLINICAL PRACTICE
ISSN
0168-8227JCR Link
Citation
vol. 82, pp. S42 - S45
Keywords
AntioxidantDiabetic nephropathyMitochondrial electron gradientNADPH oxidaseOxidative stressProtein kinase CReactive oxygen species
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
There is an increasing evidence that reactive oxygen species (ROS) play a major role in the development of diabetic complications. Oxidative stress is increased in diabetes and the overproduction of ROS in diabetes is a direct consequence of hyperglycemia. Various types of vascular cells including renal cells are able to produce ROS under hyperglycemic condition. Both NADPH oxidase and mitochondrial electron gradient play roles in hyperglycemia-induced ROS generation. In addition to their ability to directly inflict macromolecular damage, ROS can function as signaling molecules. ROS mediate hyperglycemia-induced activation of signal transduction cascades and transcription factors leading to transcriptional activation of profibrotic genes in the kidney, Furthermore, ROS-activated signaling molecules generate and signal through ROS and thus ROS act as a signal amplifier. Intensive glycemic control and inhibition of angiotensin II delay the onset and progression of diabetic nephropathy, in part, through prevention of overproduction of ROS. Conventional and catalytic antioxidants have been shown to prevent or delay the onset of diabetic nephropathy. Combination of strategies, to prevent overproduction of ROS and to increase the removal of preformed ROS may prove to be effective in preventing the development and progression of diabetic nephropathy. (C) 2008 Published by Elsevier Ireland Ltd.
DOI
10.1016/j.diabres.2008.09.017
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE