View : 14 Download: 0

Safety Aspect of Inorganic Layered Nanoparticles: Size-Dependency In Vitro and In Vivo

Title
Safety Aspect of Inorganic Layered Nanoparticles: Size-Dependency In Vitro and In Vivo
Authors
Choi, Soo-JinOh, Jae-MinChoy, Jin-Ho
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2008
Journal Title
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN
1533-4880JCR Link
Citation
vol. 8, no. 10, pp. 5297 - 5301
Keywords
SafetySize-DependencyLayered Double HydroxideIn VitroIn Vivo
Publisher
AMER SCIENTIFIC PUBLISHERS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
In past decades, much attention has focused on the potential of inorganic nanoparticles as drug or gene delivery carriers due to their high cellular uptake capacity, non immunogenic response, and low toxicity. Layered double hydroxide (LDH), so-called anionic clay, is one of the most promising candidates for various biological purposes. Our previous report demonstrated that LDH had no significant cytotoxic effects at the concentration level of practical usage in human cell lines as well as in red blood cells. In this study, the optimum size of LDH nanoparticles was determined based on their toxicity in vitro and in vivo. Size-dependent toxicity of LDH was examined in cultured human lung cells; 50 nm particles were determined to be more toxic than larger particles, while LDHs within the size range of 100 to 200 nm exhibited very low cytotoxicity in terms of cell proliferation, membrane damage, and inflammation response. In animal model, all different-sized LDHs did not cause any mortality or body weight loss up to 600 mg/kg. Therefore, LDH is an attractive biocompatible delivery carrier for biological and medical applications.
DOI
10.1166/jnn.2008.1143
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE