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Conditional exact tests for dichotomous data in the comparison of two treatments with one control group

Title
Conditional exact tests for dichotomous data in the comparison of two treatments with one control group
Authors
Kong, Seung-HoChoi, Suktae
Ewha Authors
강승호
Issue Date
2008
Journal Title
DRUG INFORMATION JOURNAL
ISSN
0092-8615JCR Link
Citation
vol. 42, no. 4, pp. 337 - 347
Keywords
Dunnett's testmultiple comparisonexact power2 x 3 contingency tabletwo-step closed Fisher's exact test
Publisher
SAGE PUBLICATIONS INC
Indexed
SCOPUS WOS scopus
Abstract
When we compare two treatments with one control group for dichotomous data whose response rates are expected to be small, Dunnett's test based on the large sample theory is unreliable. Hence, exact tests that are reliable in the cases of either small response rate or small samples need to be developed. In this article, we investigate the exact unconditional powers of the three exact tests (the two-step closed Fisher's exact test, the exact conditional Dunnett test, and the new conditional exact test proposed here). The exact unconditional power is computed based on complete enumeration. In many phase 3 clinical trials, two possible optimal doses from phase 2 clinical trials are expected to be more promising than the control. Therefore, the response rates of two possible optimal closes are greater than that of the control group. In such cases, we show that the new exact test is more powerful than the other two exact tests.
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자연과학대학 > 통계학전공 > Journal papers
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