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Current status and future perspective for the mechanism of action of dietary polyphenols on epigenetic mechanisms

Title
Current status and future perspective for the mechanism of action of dietary polyphenols on epigenetic mechanisms
Authors
Lee, Won Jun
Ewha Authors
이원준
SCOPUS Author ID
이원준scopus
Issue Date
2007
Journal Title
KOREAN JOURNAL OF GENETICS
ISSN
0254-5934JCR Link
Citation
vol. 29, no. 4, pp. 537 - 546
Keywords
polyphenolsDNA methylationhistone methylationcancer prevention
Publisher
GENETICS SOC KOREA
Indexed
SCOPUS WOS scopus
Abstract
DNA methylation and histone modifications are two major epigenetic mechanisms that can affect gene expression through chromatin structure. Although many dietary polyphenolic compounds have strong cancer-preventive effects in various cancers, the modulating effect of dietary polyphenols on DNA methylation and histone methylation status has still not been characterized very well. DNA methylation and histone methylation. can each modulate gene expression separately, there is growing evidence that an interplay exists between cytosine methylation and histone modification to from a transcriptionally inactive chromatin state. Therefore, the ability of dietary polyphenols to inhibit DNA methylation may also modulate the key parameters of histone methylation and reactivate the expression of tumor suppressor genes in cancer cells. However, it is hypothesized that all dietary polyphenols may not be the same in terms of reactivating silenced genes and modulating the methylation status of histone proteins due to the fact that each polyphenol has varying degrees of inhibition protencies and dfficacies. More studies are warranted to further test these unknown hypotheses.
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신산업융합대학 > 체육과학부 > Journal papers
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