Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-27T02:08:39Z | - |
dc.date.available | 2016-08-27T02:08:39Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.other | OAK-4082 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216109 | - |
dc.description.abstract | To develop new COX-2 inhibitors, 1,5-diarylhydantoins and 1,5-diaryl-2-thiohydantoins were synthesized from phenylacetic acids by esterification, bromination, C-N bond formation and cyclization. Esters 1-3 were efficiently synthesized from the starting materials by reflux in absolute methanol for 3 h containing concentrated sulfuric acid as catalyst. Bromination was carried out with N-bromosuccinimide at rt in dichloromethane. Bromides 4-6 were reacted with aniline, p-anisidine, sulfanilamide in ethanol (or NN-dimethylformamide) to provide the amines 7-15. Hydantoins and 2-thiohydantoins 16-46 were synthesized from amines 7-15 by treating them with potassium isocyanate (or potassium thiocyanate) and triethylamine. The synthetic process from alkyl alpha-anilinophenylacetate 7-15 to 3-alkylhydantoins was carried out in a one-pot reaction using alkyl isocyanate (alkyl isothiocyanate). | - |
dc.language | English | - |
dc.publisher | KOREAN CHEMICAL SOC | - |
dc.subject | diarylhydantoins | - |
dc.subject | diaryl-2-thiohydantoins | - |
dc.subject | hydantoins | - |
dc.subject | synthesis | - |
dc.subject | COX-2 inhibitors | - |
dc.title | Synthesis and characterization of novel hydantoins as potential COX-2 inhibitors: 1,5-diairylhydantoins | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 751 | - |
dc.relation.lastpage | 757 | - |
dc.relation.journaltitle | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.identifier.wosid | WOS:000247506700008 | - |
dc.identifier.scopusid | 2-s2.0-34249108868 | - |
dc.author.google | Park, Hae-Sun | - |
dc.author.google | Choi, Hee-Jeon | - |
dc.author.google | Shin, Hea-Soon | - |
dc.author.google | Lee, Sang Kook | - |
dc.author.google | Park, Myung-Sook | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |