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Synthesis and biological evaluation of arylsulfonylpiperazine derivatives as 5-HT6 receptor ligands

Title
Synthesis and biological evaluation of arylsulfonylpiperazine derivatives as 5-HT6 receptor ligands
Authors
Jeon, Sun AhChoo, HyunahPark, Woo-KyuRhim, HyewhonKo, Soo Y.Cho, Yong SeoKoh, Hun YeongPae, Ae Nim
Ewha Authors
고수영
SCOPUS Author ID
고수영scopus
Issue Date
2007
Journal Title
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN
0253-2964JCR Link
Citation
vol. 28, no. 2, pp. 285 - 291
Keywords
serotonin5-HT6 receptorantagonists
Publisher
KOREAN CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The 5-HT6 antagonists are mainly related to the treatment of cognitive dysfunction or impairment associated with Alzheimer's disease and schizophrenia. There have been lots of efforts to develop 5-HT6 antagonists. As in our efforts, arylsulfonylpiperazine derivatives 1-3 were designed, synthesized and biologically evaluated against the human recombinant 5-HT6 serotonin receptor. Total 36 compounds were synthesized and the most active compound among the synthesized compounds is compound 2h with an IC50 value of 1.5 mu M. The compound 2h is novel as 5-HT6 receptor ligand and could act as lead for the novel 5-HT6 receptor ligands.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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