View : 14 Download: 0

Fine tuning of a reported synthetic route for biologically active flavonoid, baicalein

Title
Fine tuning of a reported synthetic route for biologically active flavonoid, baicalein
Authors
Kim, SangheeSohn, Dae WonKim, Youn ChulKim, Soon-AiLee, Sang KookKim, Hak Sung
Ewha Authors
이상국
Issue Date
2007
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link
Citation
vol. 30, no. 1, pp. 18 - 21
Keywords
baicaleinflavonoidmodified synthesisimproved synthetic route
Publisher
PHARMACEUTICAL SOCIETY KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
A modified procedure of a previous synthetic route for baicalein was developed in order to obtain more than ten grams of baicalein for in vivo test. There were several difficulties in applying the published experimental procedures for a large scale of synthesis. The modified synthetic work was successfully accomplished by reducing amount of strong Lewis acid in Fries rearrangement and using tetrabutylammonium iodide as an additive to speed up the demethylation reaction in refluxing HBr into completion.
DOI
10.1007/BF02977773
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE