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ChimerDB - a knowledgebase for fusion sequences
- Title
- ChimerDB - a knowledgebase for fusion sequences
- Authors
- Kim, Namshin; Kim, Pora; Nam, Seungyoon; Shin, Seokmin; Lee, Sanghyuk
- Ewha Authors
- 이상혁
- SCOPUS Author ID
- 이상혁
- Issue Date
- 2006
- Journal Title
- NUCLEIC ACIDS RESEARCH
- ISSN
- 0305-1048
- Citation
- NUCLEIC ACIDS RESEARCH vol. 34, pp. D21 - D24
- Publisher
- OXFORD UNIV PRESS
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Chromosome translocation and gene fusion are frequent events in the human genome and are often the cause of many types of tumor. ChimerDB is the database of fusion sequences encompassing bioinformatics analysis of mRNA and expressed sequence tag (EST) sequences in the GenBank, manual collection of literature data and integration with other known database such as OMIM. Our bioinformatics analysis identifies the fusion transcripts that have non-overlapping alignments at multiple genomic loci. Fusion events at exon-exon borders are selected to filter out the cloning artifacts in cDNA library preparation. The result is classified into two groups-genuine chromosome translocation and fusion between neighboring genes owing to intergenic splicing. We also integrated manually collected literature and OMIM data for chromosome translocation as an aid to assess the validity of each fusion event. The database is available at http://genome.ewha.ac.kr/ChimerDB/ for human, mouse and rat genomes.
- DOI
- 10.1093/nar/gkj019
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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