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ChimerDB - a knowledgebase for fusion sequences

Title
ChimerDB - a knowledgebase for fusion sequences
Authors
Kim, NamshinKim, PoraNam, SeungyoonShin, SeokminLee, Sanghyuk
Ewha Authors
이상혁
SCOPUS Author ID
이상혁scopus
Issue Date
2006
Journal Title
NUCLEIC ACIDS RESEARCH
ISSN
0305-1048JCR Link
Citation
vol. 34, pp. D21 - D24
Publisher
OXFORD UNIV PRESS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Chromosome translocation and gene fusion are frequent events in the human genome and are often the cause of many types of tumor. ChimerDB is the database of fusion sequences encompassing bioinformatics analysis of mRNA and expressed sequence tag (EST) sequences in the GenBank, manual collection of literature data and integration with other known database such as OMIM. Our bioinformatics analysis identifies the fusion transcripts that have non-overlapping alignments at multiple genomic loci. Fusion events at exon-exon borders are selected to filter out the cloning artifacts in cDNA library preparation. The result is classified into two groups-genuine chromosome translocation and fusion between neighboring genes owing to intergenic splicing. We also integrated manually collected literature and OMIM data for chromosome translocation as an aid to assess the validity of each fusion event. The database is available at http://genome.ewha.ac.kr/ChimerDB/ for human, mouse and rat genomes.
DOI
10.1093/nar/gkj019
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자연과학대학 > 생명과학전공 > Journal papers
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