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pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)

Title
pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)
Authors
Cho, JYLee, JGutowska, ATarasevich, BJSohn, YSJeong, B
Ewha Authors
손연수정병문
SCOPUS Author ID
손연수scopus; 정병문scopus
Issue Date
2006
Journal Title
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
ISSN
1773-2247JCR Link
Citation
vol. 16, no. 1, pp. 71 - 76
Keywords
poly(aspartic acid)thermosensitive polymerpH sensitive polymersol-gel transitionhydrogel
Publisher
EDITIONS SANTE
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared. The polymer showed lower critical solution temperature in water depending on the pH as well as ionic strength. As the temperature increased, the concentrated poly(propylene glycol) aqueous solution precipitated, whereas the concentrated aqueous solution of PA-g-PPG underwent sol-to-gel transition atpH 7.4. The dehydration of poly(propylene glycol) and ionic repulsion of aspartic acid drive gel formation atpH 7.4 over 30 similar to 50 degrees C. The PA-g-PPG is expected to be a useful in situ gel forming depot system for drug delivery and tissue engineering applications.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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