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Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells
- Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells
- Joung, KE; Kim, DK; Sheen, YY
- Ewha Authors
- 신윤용; 김대기
- SCOPUS Author ID
- 신윤용; 김대기
- Issue Date
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- vol. 27, no. 6, pp. 640 - 645
- T47D cell; trichostatin A; HC-toxin; histone deacetylase
- PHARMACEUTICAL SOCIETY KOREA
- SCIE; SCOPUS; KCI
- Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. Trichostatin A, an antifungal antibiotic, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. In this study, we have examined the anti proliferative activities of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer, T47D cells. Both trichostatin A and HC-toxin showed potent antiproliferative efficacy and cell cycle arrest at G(2)/M in T47D human breast cancer cells in a dose-dependent manner. Trichostatin A caused potent apoptosis of T47D human breast cancer cells and trichostatin A-induced apoptosis might be involved in an increase of caspase-3/7 activity. HC-toxin evoked apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity. We have identified potent activities of anti-proliferation, apoptosis, and cell cycle arrest of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer cell line T47D.
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