Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-27T02:08:10Z | - |
dc.date.available | 2016-08-27T02:08:10Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-2194 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215817 | - |
dc.description.abstract | Trichostatin A, an antifungal antibiotics, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. In this study, the antiproliferative activities of trichostatin A and HC-toxin were compared between estrogen receptor positive human breast cancer cell MCF-7 and estrogen receptor negative human breast cancer cell MDA-MB-468. Trichostatin A and HC-toxin showed potent anti proliferative activity in both MCF-7 and MDA-MB-468 cells. In MCF-7 cells that contain high level estrogen receptor, trichostatin A and HC-toxin brought about three-times more potent cell growth inhibitory effect than estrogen receptor negative MDA-MB-468 cells. Both trichostatin A and HC-toxin showed cell cycle arrest at G(2)/M phases of MCF-7 and MDA-MB-468 cells in a dose- and time-dependent manner. Trichostatin A and HC-toxin also induced apoptosis from MCF-7 and MDA-MB-468 cells in a dose- and time-dependent manner. Results of this study suggested that antiproliferative effects of trichostatin A and HC-toxin might be involved in estrogen receptor signaling pathway, but cell cycle arrest and apoptosis of trichostatin A and HC-toxin might not be involved in estrogen receptor system of human breast cancer cells. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | * |
dc.subject | MCF-7 | * |
dc.subject | MDA-MB-468 | * |
dc.subject | human breast cancer cell | * |
dc.subject | estrogen receptor | * |
dc.subject | trichostatin A | * |
dc.subject | HC-toxin | * |
dc.subject | HDAC | * |
dc.title | Estrogen receptor enhances the anti proliferative effects of trichostatin a and HC-toxin in human breast cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 554 | * |
dc.relation.lastpage | 561 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/BF02980131 | * |
dc.identifier.wosid | WOS:000221753400015 | * |
dc.identifier.scopusid | 2-s2.0-16544367723 | * |
dc.author.google | Min, KN | * |
dc.author.google | Cho, MJ | * |
dc.author.google | Kim, DK | * |
dc.author.google | Sheen, YY | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |