Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서명은 | * |
dc.date.accessioned | 2016-08-27T02:08:48Z | - |
dc.date.available | 2016-08-27T02:08:48Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-1398 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215575 | - |
dc.description.abstract | Reaction between 2,3-dichloronaphthoquinone (I) and ethyl cyanoacetate or diethyl malonate under different conditions gave the starting materials, 2-chloro-3-(alpha-cyano-alpha-ethoxycarbonyl-methyl)-1,4-naphthoquinone (A) or 2-chloro-3-(diethoxycarbonyl-methyl)-1,4-naphthoquinone (B). The 2-amino-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives [A-(1-10)] and 2-hydroxy-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives [B-(1-12)] were prepared from compounds A and B, respectively, by using various alkyl-, and arylamines. The cytotoxic activities of the prepared compounds were evaluated by SRB (Sulforhodamine B) assay against the following tumor cell lines: A459 (human lung), SK-OV-3 (human ovarian), SK-MEL-2 (human melanoma), XF498 (human CNS), and HCT 15 (human colon). Many of the derivatives mentioned exhibited more potent cytotoxic effects against SK-OV-3 and XF498 than etoposide. Significantly, 2-amino-3-ethoxycarbonyl-N-(3-methyl-phenyl)-benzo[f]indole-4,9-dione (A-8) showed potent activity against all tumor cell lines, and in particular, its cytotoxic effect against SK-OV-3 was much higher than doxorubicin. (C) 2003 Elsevier Science Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.title | Synthesis and cytotoxicity evaluation of 2-amino- and 2-hydroxy-3-ethoxycarbonyl-N-substituted-benzo[f]indole-4,9-dione derivatives | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1511 | * |
dc.relation.lastpage | 1519 | * |
dc.relation.journaltitle | BIOORGANIC & MEDICINAL CHEMISTRY | * |
dc.identifier.doi | 10.1016/S0968-0896(03)00062-2 | * |
dc.identifier.wosid | WOS:000181715100035 | * |
dc.identifier.scopusid | 2-s2.0-0141947142 | * |
dc.author.google | Lee, HJ | * |
dc.author.google | Suh, ME | * |
dc.author.google | Lee, CO | * |
dc.contributor.scopusid | 서명은(7103253844) | * |
dc.date.modifydate | 20240423081003 | * |