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Screening for antiproliferative effects of cellular components from lactic acid bacteria against human cancer cell lines

Title
Screening for antiproliferative effects of cellular components from lactic acid bacteria against human cancer cell lines
Authors
Kim, JYWoo, HJKim, YSLee, HJ
Ewha Authors
김영석
SCOPUS Author ID
김영석scopus
Issue Date
2002
Journal Title
BIOTECHNOLOGY LETTERS
ISSN
0141-5492JCR Link
Citation
vol. 24, no. 17, pp. 1431 - 1436
Keywords
antiproliferative effectcytoplasm fractionlactic acid bacteriapeptidoglycantumor cell line
Publisher
KLUWER ACADEMIC PUBL
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Whole cells, cytoplasms and peptidoglycans of ten different lactic acid bacteria (LAB) were tested for in vitro cytotoxicity on diverse cancer cell lines using the H-3-thymidine incorporation assay. The peptidoglycans and cytoplasm fractions, as well as heat-killed whole cells of LAB, had significant antiproliferative activities against several cancer cell lines. In particular, the cytoplasm fractions exhibited marked direct antiproliferative activities against colon and gastric cancer cell lines, whereas the peptidoglycans retarded growth of colon and bladder cancer cell lines. The cytoplasm fractions of Bifidobacterium longum and Lactococcus lactis ssp. lactis inhibited proliferation of two cancer cell lines by 50% at 33 and 23 mug ml(-1) for SNUC2A (a human colon adenocarcinoma cell line) and 17 and 11 mug ml(-1) for SNU-1 (a human gastric cancer cell line), respectively.
DOI
10.1023/A:1019875204323
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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