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Synthesis of novel D- and L-3 '-deoxy-3 '-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor

Title
Synthesis of novel D- and L-3 '-deoxy-3 '-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor
Authors
Chun, MWKim, MJJo, UHKim, JHKim, HDJeong, LS
Ewha Authors
정낙신
Issue Date
2001
Journal Title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN
1525-7770JCR Link
Citation
vol. 20, no. 4-7, pp. 703 - 706
Publisher
MARCEL DEKKER INC
Indexed
SCIE; SCOPUS WOS
Abstract
D- and L-3'-Deoxy-3'-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2'-position were synthesized, starting from D- and L-xylose as potential ribonucleotide reductase inhibitor, respectively, but they were found to be inactive against several tumor cell lines.
DOI
10.1081/NCN-100002355
Appears in Collections:
약학대학 > 약학과 > Journal papers
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