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Synthesis of novel 3 '-deoxy-3 '-C-hydroxymethyl nucleosides with conformationally rigid sugar moiety as potential antiviral agents

Title
Synthesis of novel 3 '-deoxy-3 '-C-hydroxymethyl nucleosides with conformationally rigid sugar moiety as potential antiviral agents
Authors
Chun, MWKim, MJJo, UHKim, JHKim, HDJeong, LS
Ewha Authors
정낙신
Issue Date
2001
Journal Title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN
1525-7770JCR Link
Citation
vol. 20, no. 4-7, pp. 699 - 702
Publisher
MARCEL DEKKER INC
Indexed
SCIE; SCOPUS WOS
Abstract
Based on the fact that the ring expanded 3'-C-hydroxymethyl analogue of oxetanocin A exhibited potent antiviral activity, two types of conformationally rigid 3'-C-hydroxymethyl derivatives in which 2'-hydroxyl group is linked to the 4'-position or to the 6'-position were synthesized starting from 1,2;5,6-di-O-isopropylidene-D-glucose, respectively.
DOI
10.1081/NCN-100002354
Appears in Collections:
약학대학 > 약학과 > Journal papers
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