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Cytotoxic constituents of Psoralea corylifolia

Title
Cytotoxic constituents of Psoralea corylifolia
Authors
Mar, WJe, KHSeo, EK
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2001
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link
Citation
vol. 24, no. 3, pp. 211 - 213
Keywords
Psoralea corylifoliapsoralidinangelicinpsoralencytotoxicity
Publisher
PHARMACEUTICAL SOCIETY KOREA
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 mug/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.
DOI
10.1007/BF02978259
Appears in Collections:
약학대학 > 약학과 > Journal papers
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