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In vitro activities of 2,2 '-dipyridyl against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis

Title
In vitro activities of 2,2 '-dipyridyl against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis
Authors
Ryu, JSMin, DYKim, MCKim, NSShin, MH
Ewha Authors
신명헌
Issue Date
2001
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN
1017-7825JCR Link
Citation
vol. 11, no. 1, pp. 124 - 130
Keywords
2,2 '-dipyridylTrichomonas vaginalisCandida albicansGardnerella vaginalis
Publisher
KOREAN SOC APPLIED MICROBIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
The in vitro activity of 2,2'-dipyridyl, an iron-chelator, against clinical isolates of Trichomonas vaginalis. Candida albicans, and Gardnerella vaginalis was evaluated and compared with those of four other vaginal suppositories. ornidazole, clotrimazole, povidone-iodine. and Cenacert(R) (Methylbenzethonium Chloride mixed with 9-aminoacrydine undecylenate and hydrochloric acid N-myristyl-3-hydroxy butyl amine). The 2.2'-dipyridyl killed T. vaginalis and G. vaginalis at concentrations of 410 mug/ml and 205 mug/ml, respectively, however, this agent was less active against C. albicans (80% of which was inhibited at 410 mug/ml). The inhibition of these three pathogens by 2,2'-dipyridyl was similar to clotrimazole. In addition, the effect of 2,2'-dipyridyl on the ultrastructure of T. vaginalis. C, albicans, and G. vaginalis was examined. Transmission electron microscopy indicated that 2,2'-dipyridyl induced modifications of the cellular contents and cell envelope concomitant with the degradation of the three pathogens. These results suggest that 2.2'-dipyridyl has an inhibitory effect on C. albicans and G. vaginalis, as well as T. vaginalis.
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의과대학 > 의학과 > Journal papers
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